4fgvA QGIRNFVVQYILQCSSSNLVLVSVLKQEWPHNWPTFINEIVSACHSLSVCENNMIILRLLSEEVFDYSADQMTSTKTRNLKSTMCAEFSMQLCQEILNSATQPSLIKATLETLLRFCNWIPLGYIFETPLITRFLEVPEFRNVTLQCLTEIGGLQTGGPGQPHTEQLIKMFTEVLTTISNIIP-LKATYPNSNSRDQEFIQNLALFLTSFTMHLPLIENLPNRDFLTHGHFYLIRISQIDDREIFKICLDYWLKLVQELYEEMQSLPLNDMSSMGLGMMSGGGAPNPAL-YPLRKHKEVLSNLRVVMIEKMVRPEEVLIVENDEGEIVREFVKDTD--SVQLYKTIRECLVYLTHLDVVDMEQIMTEKLARQVDGSEWSWHNCNVLCWAIGSISLVTVIKDLLGLTEMKRGKD--NKAVVASNIMYIVGQYPRFLKAHW---KFLKTVVNKLFEFMHESHEGVQDMACDTFIKIAKQCRRHFVALQPSENEPF-IEEIIRNIGKITCDLTPQQVHTFYEACGYMVSAQGN---RNQQERLLAELMAIPNAAWDEIIKAATMNPGILHEPDTIKIIGNIMKTNVSACSSIFPQIGRLYNDMLQMYAATSQLISEAVARDGEIATKMPKVRGLRTIKKEILKLVETFLQAVRSQMIPGLLDSVLVDYNRNVPGARDAEVLKAMTVIITRLQGLMEDQVPA----MENVFECTLDMINKPEHRVEFFNLLRAINLYC---FPALLKLDNRQFKFVIDSCMWASKRDVETAGLNMCLELINNIAEKTDVQTCNAFFNQFFIRILQDVFFVLT-KAGFKTQSMLLMRLF--YFVHPADGSAPKIQGPIYQPDQAQPGTGNREFLANFVGTLLQNAFANLTPLQ-ITT 3ayfA ----------------------------------------TTNSFLKSILIFTILISSTVLLVGGYWIFKEMAPRPKEVRSESGEVLMTKETIIGGQAVFQKYGLMDYPDYTAEAL-----KVYTEGMQDYKAKADLTDDEKSIIREQVIKEMRKNRYNPVTLTDAQVYGLEKVRDYYRD-------------------VFTN-----------GDGWGLKKGLIKESDMPKANRAWVADSDQIQQIADFFFWTAWLSSTLRIGDEITYTNNWPYYEDAGNT---------MSFTILILFIGIILYVFYRYQLSMQEAYAEGKFPV----IDLRRQPLTPSQVKAGKYFVVVSALFFVQTMFGALLAHYYTEPDSFF----GINWIYDIL-PFNIAKGYHLQ-------------LAIFWIATAWLGMGIFIAPLVGGQEPKKQGLLVDLLFWLVVLVGGSMIGQWLGVNGYLGNEWFLLGHQGWEYIELG----------RIWQIILVVGMLLWLFIVFRGVKRGLKRESDKGGLIHLLFYSAAVPFFYIFAFFIQPDTNFTMADFWRWWIVEGIFFAVVVIGFLLVQLRLVTKKSTVRALYFQFTILLGSGVIGIGHHYYYNGSPEVWIALGAVFSAL------EVIPLTLLILEAYEQYKMMRDGGANFPYKATFWFLISTAIWNLVGAGVFGFLINLPAVSYFEFLTPAHGHAYGMFAIAVLLYSLIVKPEAWNDKWLKFIGLAGMVVIT----LLPVGILQMKEAFIHGYWASRSPSFLQQDVVQNLLRAVPDTIFLIGVVALLVFAI--------KALFHLRKPTHGEGEE--------------------------------------------- 1qgrA MLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLEVKNYVLQCVAGIACAEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGM------RKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVA-------------------ALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEH----------TSKFYAKGALQYLVPILTQTLTKQDEN------------DDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDALEGPEPSQLKPLVIQAMPTLIELMKDPS--------VVVRDTAAWTVGRICELLPEAAINDVY-----LAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTLRSSAYESLMEIVKNSAKDCYPAVQKTTL----VIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRM-----------------FSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCNLGNENVHRSVKPQILSVFGDIALAIGGEFVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENV---HPDVMLVQPRVEFILSFIDHIAVVACAAGLIGDLCTAFGKDVLKLVEAR-----------------------------------PMIHELLTEGRRSKTNKNQA 3ea5B RILAALTLKNELVSKDTQQFAQRWITQVSPEAKNQIKTNALTALVPRIANAAAQLIAAIADELMKIMVDNTGAEQPENVKRASLLALGYMCESADPQSQVSSSNNILIAIVQGAQSTETSKAVRLAALNALADSLIFIKNNMEREGERNYLMQVVCEATQAEDIEVQAAAFGCLCKIMSKYYTFMKPYME---QALYALTIATMKSPNDKVASMTVEFWSTICEEEIDIAYELAQFPQSPLQSYNFALSSIKDVVPNLLNLLTRQNEDPEDDDWNVSMSAGACLQLFAQNCGNHI----LEPVLEFVEQNITADNWRNREAAVMAFGSIMDGPDKVQRTYYVHQALPSILNLMLQVKETTAWCIGRIADSVAESIDPQQHLPQDHPKVATNCSWTIINLVEQLAEATPSPIYNF---------YPALVDGLIGAANRIDNEFNARASAFSALTTMVEYATDTVAETSASISTFVMDKLGQTMSVDENQLT------------LEDAQSLQELQSNILTVLAAVIRKSPSSVE------PVADMLMGLFFRLLEKKDSAFIEDDVFYAISALAASLLETFSPYLLKALNSPVSITAVGFIADISNSLSDAMMNVLAQMISNPNARRELKPAVLSVFGDIASNIGADFIPYLNDIMALCVAAQNTKPENGTLEALDYQIKVLEAVLDAYVGIVAGLHDKPEAQFIAQVAEDPQLYSEDATSRAAVGLIGDIAAMFPDGSIKQFYGQ-----------------DWVIDYIKRTRSGQLFSQATKDTARWAREQQKRQLSL------------------------------------------------------------------------------------ 3ayfA TNLKSILIFTILISSTRPKEVTKETIIGGQAVFQKYMGDYTAEALKVYTEGMQDYLTDDEKSIIREQVIKEMRKNRYNPVTDVL--VLTDAQVYGLEKRDYYRDVFTNG-------DGWGLKKGLIKESDMPKANRAWVADSDQIQQIADFFFWTAWLSST----------------------------LRIGD--------EITYTNNYY--EDAGNTMSFSAVWWSGSVTILILFIG------------IILYVFYRYQLSMQEAYA----------------------EGKFPVIDLRR---------------------------------QPLTPSQVKAGKYFVVVSALFFVQTMFGALLAHYYT----EPDSFFGINWIYDIL-PFNIAKGYHLQ-------------LAIFWIATAWLGMGIFIAPLVGGQEPKQGLLVDLLFWALVVLVGGSMIGQWLGVNGYLGNEWFLL----------GHQGWEYIELGRIWQIILVVGMLLWLFIVFRGVKRGLKRESDKGGLIHLLFYSAIAVPFFYIFAFFIQPDTNTMADFWRWWIVEGIFFAVVVIGFLLVQLTKKSTVRALYFQFTILLGSGVIGIGHHY----YYNGSPEVWIALGAVFSALEVIPLT-----LLILEAYEQYKMMRDGGANFPYKATFWFLISTAIWNLVGAGVFGFLINLPAVSYFEFLTPAHGHAYGMFAIAVLLYSLIVKPEAWNDKWLKFSCWMLNIGLAGMVVLLPVGILQMKEAFIHGYWASRSPSFLQQDVVQNLLLAVPDTIFLIGVVALLVFAI--------KALFHLRKPTHGEGEE--------------------------------------------- 3w3tA ENNIEYLLTFLAEQAAAALSAVLFRKLALKAPITHI-RKEVLAQIRSSLLKGFLDSIRHKLSDAIAECVQDDLPAWPELLQALIESLKSGNPNFRESSFRILTT----VPYLITAV----DINSILPIFQSGFTDASDNVKIAAVTAFVGYFKQLPKSEWSKLGILLPSLLNSLPRFLDDGKASVFESLIELVELAPKLFKDMFDQI--IQFTDMVIKNKDLEPPELLTVFSENAPQMCKSNQNYGQTL-VMVTLIMMTEVSIDDDDAAEWIESDDTDDEEEVTYDHARQALDRVALKLLAAPLFQYLQQMIEGCADVLIGEIPKILDMVIPLINDPHPRVQYGCCNVLGQISTDFIQRTAHDRILPALISK--TSECTSRVQTHAAAALVNFSLDSLLTNLLVLLQSNKLYVQEQALTTIAFIAEAAKNKFYYDTLMPLLLNVLKVNSVLKGKCMECAGFAVGKEKFHEHSQELISILVALQNSDDDALRSYLEQSWSRICRILLPIVIPPLLITALIEEEEAANFQQYPDWDVVIHTSVLDDKVSAMELLQSYATLLRGQFAVYVKEVMEEIALPSLDGVRAAGATLIPILLSCLLAATEELVLLWHKASSKLIGGLMSEPMPEITQVYHNSLVNGIKVMGDNLAAFTKGVSANLTDTYERMQDRDEYNEFTDEDLLDEINKSIAAVLKTTNGHYLK--NLENIWPMINTFLLPILVIFALVVIGDLIQYQTASMKNAFIPSYIIGVCAQYAYADVCIPTLDTLVQIVDGSKLEENRSSTENASAAIAKILYAYDTYTANWFKTLPTKEAASFNYQFLSQLI-------ENSNISAVVDSVIQALNERSLTVISSVKKLLGFLPSSDAMAIFNRYPADIM 4bgrN REMAALIASKVYYNLGEYESAVKYALAAKDRFDIDEKSQFVETIVSKSIEMYVQEASKQYTKDEQFYTKDIIDPKLTSIFERMIEKCLKASELKLALGIALEGYRLDIIESALKSKLDQSTSENVKIINYLLTLAITTVTNSKFRSSILRKSFDFLMNMPNCD----YLTLNKVVVNL-NDAGLALQLFKK------------LKEENDEGLSAQIAFDLVSSASQQLLEILVTELTAQGYDPALLNILSGLPTCDYYNTFLLNNKNIDIGLLNKSKSSLDGKF-----------SLFHTAVSVANGFMHAGTTDNSFIKANLPWL---------GKAQNWAKFTATASLGVIHKGNLLEGKKVMAPYLPGSRASSRFIKGGSLYGLGLIYAGFTTDYLKNIIVENSGTSGDEDVDVLLHGASLGIGLA------AMGSANIEVYEALKEVLATSGEAAALGMGLCMLGTGPEAIHDMFTYSQETQHGNLINYGRQELADDLITKMLASDESLLRYGGAFTIALAYAGTGRLLHVAVSDSNDDVRRAAVIALGFVLLRDYTTVPRIVQLLSHNAHVRCGTAFALGIACAGKGLQSAIDVLDPLTKDFVRQAAMIALSMILIQQTEKLNPQVADINKNFLSVITNKHQEGLAKFGACVAQGIMNAGGRNVTIQLENADTGTLDTKSVVGLVMFS-----QFWYWFPLAHFLSLSFTPTT---------VIGIRGSDQAIPKF------------------------QMNCYAKEDAFSYPRMKYSSKPYKV-----------------------------------DNMTRILPQQSRYISFIKDDRFVPVRKFKGNNGVVVLRDREPKEPVALIETVRQMKD 1u6gC ASYHFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDKNGEVQNLAVKCLGPLV-----------SKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTV-------IGELPSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLATIIALGHLVMS-----------CFVDLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREYRCPKEVYPHVSTIINICLKYLTYDMSWKVRRAAAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQC--CFNMLTELVNVLPGALTQHIPVLVPGISNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVA--CVGDPFYKITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLVKERAISCMGQIICNLGDNLGSDLPNTLQIFLERTRLTTVKALTLIAGSPLKIDL--------RPVLGEGVPILASFLRKNQRALKLGTLSALDILIKNAAMIDAVLDELPPLISESDMHVSQMAISFLTTLAKVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVTNNLGYMDLLRMLTGPVYSQTHKQSYYSIAKCVAALTRACEGPAVVGQFIQDVKNSRSTDSIRLLALLSLGEVGHHIELKSVILEAFSSPSESYALGSISVGNLPEYLPFVLQEIRQYLLLHSLKEIISPYVENIWALLLKHCECAEEGKGYLISGSSYISDHPQPIDPLLKNCIGDFLKTLEDPDLNETKVRKELI 1qgkA RVAAGLQIKNSLTSKDPDIKAQYQQRWLADANARREVKNYVLHTLGTETYRPSSASQCVA-GIACAEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGY------ICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAA-------------------LQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFY---------AKGALQYLVPILTQTLTKQDEND-------------DDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDALEGPEPSQLKPLVIQAMPTLIELMKDPS----------VVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRDALQISDVVMASLLRMFQSTGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNRSVKPQILSVFGDIALAIYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDV--MLVQP----------RVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEAR----------PMIHELLTEGRRSKTNKAKTLARWATKELRKLKNQA----------------------------- 3aqpA -DLGVFLLALLFVWKPAPEEPKGLLKGGLRIVLEADVENPTLDDLEKARTVL--ENRINALGVAEPLIQIQGQSQADQDRALKLIGQRAVLEFRIVKEGAT--GTTVAQINQALRENPRLNREELEKDLIKPEDLGPPLLTGADLADARAVFD----------------QFGRPQVSLTFTPEGAKKFEEVTRQNI-GVLDGRVYTAPV------IRQAITGGQAVIEG------------------LSSVEEASEIALVLRSGSL------------PVPLKVAEIRAIGP-TLGQDAIQAGIRSALIGT----------------------------LAIFLLIFAYPHLGLVASLGLLYTSALILGLLSGLGATLTL---PGIAGLVLTLGAAVDGNVLSELRAGKKLRQAIPEGFRHSTLTIMDVNIAHLLA----AAALYQYATGPVRGFAVILAIGVVASVFSNLV-FSRHLLERLADRGEIRPPMWLVDPRFNFMGPARYVTAATLLLAALAAGVVFA---KGFNY--------------SIDFTAYTLRAEPNVEVETLRRFLEEKGF----PGKEAVITQVYRE-FLVKLPPLSDERRLELERLFASELKATVL------ASETVGPAIGEELRRNAVMAVLVGLGLILLYVAFRFD-------WTFGVASILAVAHDVAIVAGMYSLLGL-EFSIPTIAALLTI--VGYSINDSIVVSDRIRLRHLPYAELVNRSINQTLSRTVMTSLTTLLPILALLFL-----------------GGSVLRDFALAIFVGIFVGTYSSIYVVSALVVAWKNR----------------------------------------------------------