Drug target from Brugia malayi(Filarial nematode worm)



General Information  
   
FiloBase ID FDT012
Protein Name PAN domain containing protein
EMBL ID DS239406
UniProtKB/TrEMBL ID A8PUY2
GenBank ID 170587418
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_35120 
Taxonomic Identifier 6279
Source Brugia malayi(Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_35120 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software I-TASSER (Iterative Threading ASSEmbly Refinement)
Method Threading
   
Templates 4a2l 
2f83 
2ecf 
2cn2 
3s8v 
3nk3 
3nk4 
3zkv 
4dur 
3s8v 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL. Draft genome of the filarial nematode parasite Brugia malayi. Science. 2007 Sep 21;317(5845):1756-60.
PubMed ID 17885136
Full text link Full text   


General Information  
   
FiloBase ID FDT012
Protein Name PAN domain containing protein
EMBL ID DS239406
UniProtKB/TrEMBL ID A8PUY2
GenBank ID 170587418
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_35120 
Taxonomic Identifier 6279
Source Brugia malayi(Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_35120 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software I-TASSER (Iterative Threading ASSEmbly Refinement)
Method Threading
   
Templates 4a2l 
2f83 
2ecf 
2cn2 
3s8v 
3nk3 
3nk4 
3zkv 
4dur 
3s8v 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL. Draft genome of the filarial nematode parasite Brugia malayi. Science. 2007 Sep 21;317(5845):1756-60.
PubMed ID 17885136
Full text link Full text   


 Sequene
FASTA format   Full sequence
M L P S L F M R L L L L L L T C C A T I S W A V F E C A S H E T T A F V R I A R A R L S G T P V V V S T A G H D L T C A Q Y C R N N I E P T T G A Q R V C A S F N F D G R E T C Y F F D D A A T P A G T A N L A S N P S A N N F Y Y E K T C I P G V S A H E A C T Y R S F S F E H T R K T A L E G F V R K S V Q V G S R E Q C L S A C L K E E E F V C R S V N Y N Y D T Y L C E L S T E D R R S K P N H L R H S D S P V D Y Y D N N C L S R Q N R C G E A G G N L V F V K T T N F E I H F Y D H T Q S V E A Q E S F C L Q K C L D S L N T F C R S V E F S P S E K N C I V S D E D T F S R A D Q Q G H I Q G K D Y Y E P V C V A A D L S S S T C R Q Q A A F E R F I G S Q I D G Q P V A S A Q G V T L S D C I S L C F Q N L N C K S I N Y D R T Q M T C Y V F S V G R S D A N I K P N P S T D F Y E F N C E S Q F G G M A L C T N E G I R F I V N T K E P Y T G A I Y A A E R F G T C S Q V V E N A K Q I S I N F P P T Y C D G K L E A L V V V S L D G V L P H Q V T T E W D R F Y R V S C D I S M D K M M H E G S V I V T T I Y D A G E T N T R V L A V G T P P P V T A T L S F L S D D D E L L E K A S I G D S I Q M V V T S E Q A G P H N M M L T E C T A T R V G G E G D A V P F T I I E N G C P R Y P A L V G P V R Q D F E K N R L K C D M K A F R L D G S Y D V Q I L C Q V M F C A G P N G C P P S N C L D S G T N E L F M S H G R R K R S V D E N D Q T E G T L S A I I R V L A K G E N E E V L Q N A T F P N N T F S E E F D L V C M S E V W F I S S V V S V S V V C L I L S A F I V V W G C S S L K K E K L P L

The amino acid color is based upon Bob Fletterick's 'Shapely Models'.(Ref. & Table)
 Sequene Length

734  amino acid

 Secondary Structure
Graphical View

Notice: Undefined variable: result in /opt/lampp/htdocs/filobase/drugt.php on line 193
C C H H H H H H H H H H H H H H H H H H C C C C C C C C C C C S S S S S S S C C S S C C C C C C S S S C C C C H H H H H H H H C C C C C C C C C C C C C C S C S S S C C C C S S S S S C C C C C C C C C C C C C C C C C C C C S S S S S S C C C C C C C C C C C C C C C S S S S S S C C C C C C C C C C C S S C C C C H H H H H H H H C C C C C C C S S S S S S S C C C C S S S S C C C C C C C C C H H C C C C C C C S S S S S C C C C C C C C C C C C C C C C S S S S S S C C C S C C C S S S S S S C C C C H H H H H H H H H H C C C C C S S S S S S C C C C C C S S S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C S S S S C C C C C C C C C C S S S C C C C C C H C C H H C C C C C C C C C S S S C C C C C C S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C S S C C C C C C C C C H H C C C C C C C C S S S C C C C C S S S S S S S S C C C C C S S S S S S S S S S S S S S S C C S S S S C C S S S S S S S S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C S S S S S C C C C C C C S C S S S S C C C S S S S S S S S C C C C C C S S S S S S S S S S C C C C C C C C S S S S S S C C C C C C C H H H C C C C S S C C C C C S S S S S S S S S S C C C C C S S S S S S S S S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C S S S S S C C C C C C C C C C C C C C C C C C C C C C C C C S S S C H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H C C C C C C

 Solvent Accessibility
7 2 1 2 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 2 2 3 3 4 1 3 4 6 4 2 1 0 0 1 1 1 2 3 1 3 1 4 3 4 4 3 3 2 2 4 2 3 3 2 4 2 0 1 4 1 0 3 5 3 4 4 3 3 4 3 3 3 2 3 0 1 0 0 2 1 4 3 4 3 2 0 2 0 1 1 3 4 3 4 4 3 3 4 3 3 2 3 3 3 3 5 2 2 1 1 1 0 1 1 1 1 1 4 4 4 3 3 3 6 4 0 4 4 2 2 0 0 0 2 3 0 3 4 3 3 0 3 3 2 2 3 3 3 2 4 2 2 3 2 4 2 0 2 4 2 0 2 7 3 5 4 1 3 0 2 0 0 1 0 2 3 6 4 2 2 0 2 0 2 2 3 2 3 4 3 3 3 4 3 1 3 3 7 6 2 2 0 1 0 0 0 1 0 0 0 3 3 4 3 3 2 4 4 3 3 1 2 0 0 0 1 2 0 3 3 2 3 0 3 3 2 2 3 3 3 2 4 3 3 3 3 4 3 0 2 3 2 0 1 6 4 4 5 1 3 0 2 0 0 2 1 4 4 3 3 2 2 0 2 0 2 3 3 2 3 2 2 3 3 4 4 3 3 3 2 3 3 2 3 1 0 2 3 1 3 2 5 3 4 1 2 4 3 3 3 4 3 4 2 0 0 2 2 0 2 3 2 3 2 3 3 3 3 2 3 3 3 4 3 3 3 3 5 2 0 2 4 3 0 3 4 3 2 3 0 2 0 0 1 1 2 3 2 3 1 2 0 2 1 1 2 1 3 3 3 3 2 2 2 2 2 3 1 2 2 2 2 2 3 2 3 2 3 2 3 2 3 2 3 1 2 3 3 3 5 3 2 3 0 3 0 3 3 3 3 2 1 2 0 1 1 1 0 3 2 2 2 3 2 0 2 2 3 2 4 3 3 3 3 0 2 0 2 0 2 1 3 3 1 2 1 3 2 3 1 1 0 2 0 1 0 1 0 1 2 2 3 3 0 1 2 4 2 3 3 3 0 3 0 2 0 3 1 3 3 5 4 3 3 3 4 3 4 2 3 2 2 3 2 2 3 3 4 4 3 3 2 3 3 1 2 3 3 3 2 2 1 0 2 0 1 0 2 1 2 3 4 4 3 3 2 2 2 2 0 3 0 1 1 2 0 1 0 2 0 2 0 3 4 4 2 2 0 0 0 0 0 2 2 0 0 0 2 1 3 6 2 4 5 4 4 2 2 1 1 0 0 3 3 0 0 1 2 2 3 4 0 0 2 3 0 3 3 3 4 4 4 3 2 0 2 0 1 0 2 0 1 1 0 0 3 3 4 2 0 2 0 1 0 1 0 1 0 0 2 4 5 6 6 1 4 2 3 4 0 4 4 4 4 4 4 6 4 4 4 3 4 4 1 3 3 1 3 2 4 5 4 6 4 3 4 4 3 1 3 3 3 0 3 2 1 3 3 3 4 5 4 4 3 3 4 5 4 4 3 4 5 4 4 3 4 6 5 4 3 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 1 1 0 2 1 0 0 0 0 0 0 0 1 2 2 3 4 3 5 7
Values range from 0 (buried residue) to 9 (highly exposed residue)

 Download the alignment file (Protein and Template )
 
 Download Models

Model 1 Model 2 Model 3 Model 4 Model 5


Ramachandran Plot

Checks the stereochemical quality of a protein structure by analyzing residue-by-residue geometry and overall structure geometry.   Click here for Ramachandran plot of FDT012
ERRAT

Analyzes the statistics of non-bonded interactions between different atom types and plots the value of the error function versus position of a 9-residue sliding window, calculated by a comparison with statistics from highly refined structures.  Click here for ERRAT plot ofFDT012
PROVE

Calculates the volumes of atoms in macromolecules using an algorithm which treats the atoms like hard spheres and calculates a statistical Z-score deviation for the model from highly resolved (2.0 or better) and refined (R-factor of 0.2 or better) PDB-deposited structures.    Click here for PROVE plot of FDT012

  
                                   Active site residues                                      
Pockets   On  Off Residues
Site 1      395,408,424,426,427;
Site 2      54,55,47,54,85,52,58,50;
Site 3      50,52,55,57,61;
Site 4     177,179,232,260,261;
Site 5     151,185,187,189,227;
Site 6     498,576,577,578,603;
                                   Representation                                            
 
 



KEGG Pathway Not found for this protein
Drug target from Brugia malayi(Filarial nematode worm)



General Information  
   
FiloBase ID FDT012
Protein Name PAN domain containing protein
EMBL ID DS239406
UniProtKB/TrEMBL ID A8PUY2
GenBank ID 170587418
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_35120 
Taxonomic Identifier 6279
Source Brugia malayi(Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_35120 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software I-TASSER (Iterative Threading ASSEmbly Refinement)
Method Threading
   
Templates 4a2l 
2f83 
2ecf 
2cn2 
3s8v 
3nk3 
3nk4 
3zkv 
4dur 
3s8v 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL. Draft genome of the filarial nematode parasite Brugia malayi. Science. 2007 Sep 21;317(5845):1756-60.
PubMed ID 17885136
Full text link Full text   


General Information  
   
FiloBase ID FDT012
Protein Name PAN domain containing protein
EMBL ID DS239406
UniProtKB/TrEMBL ID A8PUY2
GenBank ID 170587418
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_35120 
Taxonomic Identifier 6279
Source Brugia malayi(Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_35120 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software I-TASSER (Iterative Threading ASSEmbly Refinement)
Method Threading
   
Templates 4a2l 
2f83 
2ecf 
2cn2 
3s8v 
3nk3 
3nk4 
3zkv 
4dur 
3s8v 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL. Draft genome of the filarial nematode parasite Brugia malayi. Science. 2007 Sep 21;317(5845):1756-60.
PubMed ID 17885136
Full text link Full text   


 Sequene
FASTA format   Full sequence
M L P S L F M R L L L L L L T C C A T I S W A V F E C A S H E T T A F V R I A R A R L S G T P V V V S T A G H D L T C A Q Y C R N N I E P T T G A Q R V C A S F N F D G R E T C Y F F D D A A T P A G T A N L A S N P S A N N F Y Y E K T C I P G V S A H E A C T Y R S F S F E H T R K T A L E G F V R K S V Q V G S R E Q C L S A C L K E E E F V C R S V N Y N Y D T Y L C E L S T E D R R S K P N H L R H S D S P V D Y Y D N N C L S R Q N R C G E A G G N L V F V K T T N F E I H F Y D H T Q S V E A Q E S F C L Q K C L D S L N T F C R S V E F S P S E K N C I V S D E D T F S R A D Q Q G H I Q G K D Y Y E P V C V A A D L S S S T C R Q Q A A F E R F I G S Q I D G Q P V A S A Q G V T L S D C I S L C F Q N L N C K S I N Y D R T Q M T C Y V F S V G R S D A N I K P N P S T D F Y E F N C E S Q F G G M A L C T N E G I R F I V N T K E P Y T G A I Y A A E R F G T C S Q V V E N A K Q I S I N F P P T Y C D G K L E A L V V V S L D G V L P H Q V T T E W D R F Y R V S C D I S M D K M M H E G S V I V T T I Y D A G E T N T R V L A V G T P P P V T A T L S F L S D D D E L L E K A S I G D S I Q M V V T S E Q A G P H N M M L T E C T A T R V G G E G D A V P F T I I E N G C P R Y P A L V G P V R Q D F E K N R L K C D M K A F R L D G S Y D V Q I L C Q V M F C A G P N G C P P S N C L D S G T N E L F M S H G R R K R S V D E N D Q T E G T L S A I I R V L A K G E N E E V L Q N A T F P N N T F S E E F D L V C M S E V W F I S S V V S V S V V C L I L S A F I V V W G C S S L K K E K L P L

The amino acid color is based upon Bob Fletterick's 'Shapely Models'.(Ref. & Table)
 Sequene Length

734  amino acid

 Secondary Structure
Graphical View

Notice: Undefined variable: result in /opt/lampp/htdocs/filobase/drugt.php on line 193
C C H H H H H H H H H H H H H H H H H H C C C C C C C C C C C S S S S S S S C C S S C C C C C C S S S C C C C H H H H H H H H C C C C C C C C C C C C C C S C S S S C C C C S S S S S C C C C C C C C C C C C C C C C C C C C S S S S S S C C C C C C C C C C C C C C C S S S S S S C C C C C C C C C C C S S C C C C H H H H H H H H C C C C C C C S S S S S S S C C C C S S S S C C C C C C C C C H H C C C C C C C S S S S S C C C C C C C C C C C C C C C C S S S S S S C C C S C C C S S S S S S C C C C H H H H H H H H H H C C C C C S S S S S S C C C C C C S S S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C S S S S C C C C C C C C C C S S S C C C C C C H C C H H C C C C C C C C C S S S C C C C C C S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C S S C C C C C C C C C H H C C C C C C C C S S S C C C C C S S S S S S S S C C C C C S S S S S S S S S S S S S S S C C S S S S C C S S S S S S S S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C S S S S S C C C C C C C S C S S S S C C C S S S S S S S S C C C C C C S S S S S S S S S S C C C C C C C C S S S S S S C C C C C C C H H H C C C C S S C C C C C S S S S S S S S S S C C C C C S S S S S S S S S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C S S S S S C C C C C C C C C C C C C C C C C C C C C C C C C S S S C H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H C C C C C C

 Solvent Accessibility
7 2 1 2 0 0 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 2 2 3 3 4 1 3 4 6 4 2 1 0 0 1 1 1 2 3 1 3 1 4 3 4 4 3 3 2 2 4 2 3 3 2 4 2 0 1 4 1 0 3 5 3 4 4 3 3 4 3 3 3 2 3 0 1 0 0 2 1 4 3 4 3 2 0 2 0 1 1 3 4 3 4 4 3 3 4 3 3 2 3 3 3 3 5 2 2 1 1 1 0 1 1 1 1 1 4 4 4 3 3 3 6 4 0 4 4 2 2 0 0 0 2 3 0 3 4 3 3 0 3 3 2 2 3 3 3 2 4 2 2 3 2 4 2 0 2 4 2 0 2 7 3 5 4 1 3 0 2 0 0 1 0 2 3 6 4 2 2 0 2 0 2 2 3 2 3 4 3 3 3 4 3 1 3 3 7 6 2 2 0 1 0 0 0 1 0 0 0 3 3 4 3 3 2 4 4 3 3 1 2 0 0 0 1 2 0 3 3 2 3 0 3 3 2 2 3 3 3 2 4 3 3 3 3 4 3 0 2 3 2 0 1 6 4 4 5 1 3 0 2 0 0 2 1 4 4 3 3 2 2 0 2 0 2 3 3 2 3 2 2 3 3 4 4 3 3 3 2 3 3 2 3 1 0 2 3 1 3 2 5 3 4 1 2 4 3 3 3 4 3 4 2 0 0 2 2 0 2 3 2 3 2 3 3 3 3 2 3 3 3 4 3 3 3 3 5 2 0 2 4 3 0 3 4 3 2 3 0 2 0 0 1 1 2 3 2 3 1 2 0 2 1 1 2 1 3 3 3 3 2 2 2 2 2 3 1 2 2 2 2 2 3 2 3 2 3 2 3 2 3 2 3 1 2 3 3 3 5 3 2 3 0 3 0 3 3 3 3 2 1 2 0 1 1 1 0 3 2 2 2 3 2 0 2 2 3 2 4 3 3 3 3 0 2 0 2 0 2 1 3 3 1 2 1 3 2 3 1 1 0 2 0 1 0 1 0 1 2 2 3 3 0 1 2 4 2 3 3 3 0 3 0 2 0 3 1 3 3 5 4 3 3 3 4 3 4 2 3 2 2 3 2 2 3 3 4 4 3 3 2 3 3 1 2 3 3 3 2 2 1 0 2 0 1 0 2 1 2 3 4 4 3 3 2 2 2 2 0 3 0 1 1 2 0 1 0 2 0 2 0 3 4 4 2 2 0 0 0 0 0 2 2 0 0 0 2 1 3 6 2 4 5 4 4 2 2 1 1 0 0 3 3 0 0 1 2 2 3 4 0 0 2 3 0 3 3 3 4 4 4 3 2 0 2 0 1 0 2 0 1 1 0 0 3 3 4 2 0 2 0 1 0 1 0 1 0 0 2 4 5 6 6 1 4 2 3 4 0 4 4 4 4 4 4 6 4 4 4 3 4 4 1 3 3 1 3 2 4 5 4 6 4 3 4 4 3 1 3 3 3 0 3 2 1 3 3 3 4 5 4 4 3 3 4 5 4 4 3 4 5 4 4 3 4 6 5 4 3 1 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1 0 2 1 1 0 2 1 0 0 0 0 0 0 0 1 2 2 3 4 3 5 7
Values range from 0 (buried residue) to 9 (highly exposed residue)

 Download the alignment file (Protein and Template )
 
 Download Models

Model 1 Model 2 Model 3 Model 4 Model 5


Ramachandran Plot

Checks the stereochemical quality of a protein structure by analyzing residue-by-residue geometry and overall structure geometry.   Click here for Ramachandran plot of FDT012
ERRAT

Analyzes the statistics of non-bonded interactions between different atom types and plots the value of the error function versus position of a 9-residue sliding window, calculated by a comparison with statistics from highly refined structures.  Click here for ERRAT plot ofFDT012
PROVE

Calculates the volumes of atoms in macromolecules using an algorithm which treats the atoms like hard spheres and calculates a statistical Z-score deviation for the model from highly resolved (2.0 or better) and refined (R-factor of 0.2 or better) PDB-deposited structures.    Click here for PROVE plot of FDT012

  
                                   Active site residues                                      
Pockets   On  Off Residues
Site 1      395,408,424,426,427;
Site 2      54,55,47,54,85,52,58,50;
Site 3      50,52,55,57,61;
Site 4     177,179,232,260,261;
Site 5     151,185,187,189,227;
Site 6     498,576,577,578,603;
                                   Representation                                            
 
 



KEGG Pathway Not found for this protein