Drug target from Brugia malayi (Filarial nematode worm)



General Information  
   
FiloBase ID FDT014
Protein Name Putative uncharacterized protein
EMBL ID A8Q7A6
UniProtKB/TrEMBL ID A8Q7A6
GenBank ID 158591941
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_45135 
Taxonomic Identifier 6279
Source Brugia malayi (Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_45135 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software I-TASSER (Iterative Threading ASSEmbly Refinement)
Method Threading
   
Templates 1tic 
1tgl 
3ngm 
1tia 
1dt5 
3o0d 
2yij 
3uuf 
3g7n 
1usw 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL. ;Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea
PubMed ID 17885136
Full text link Full text   


General Information  
   
FiloBase ID FDT014
Protein Name Putative uncharacterized protein
EMBL ID A8Q7A6
UniProtKB/TrEMBL ID A8Q7A6
GenBank ID 158591941
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_45135 
Taxonomic Identifier 6279
Source Brugia malayi (Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_45135 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software I-TASSER (Iterative Threading ASSEmbly Refinement)
Method Threading
   
Templates 1tic 
1tgl 
3ngm 
1tia 
1dt5 
3o0d 
2yij 
3uuf 
3g7n 
1usw 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL. ;Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea
PubMed ID 17885136
Full text link Full text   


 Sequene
FASTA format   Full sequence
M Y K V I I C L L L L T P R I A N A F K I G I G G K N R G S S A A R L N P S R P N T H S S A G G Y H Q P Q G A Y H P Q Q S G Y Y P Q Q G G Y P Q Q G G Y R P Q Q N G Y H Q T A P G G Y H P S Q I G G Y H Q Q S G F A P N Q M K P S G K G T F G K A V L G G A L G A A A G L A T F E L G K A T V L I T A I Y L D C W H I L Q L N V L H A I L R S G S E P L R A S N G Q N Y Y F D E R N H Q Y K N G Y F M C S V P I D D V L K T L Q G S S T V V A A A D E S T N S T A I S P E Q F F K T V H F K D G S R P K S L T W N C K S D A E I C C D T D C C P V Q Q L S G G N F S D H K R P S W V F F I R F V D I L K S E

The amino acid color is based upon Bob Fletterick's 'Shapely Models'.(Ref. & Table)
 Sequene Length

294  amino acid

 Secondary Structure
Graphical View

Notice: Undefined variable: result in /opt/lampp/htdocs/filobase/drugt.php on line 193
C C S S S S S S S S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C H H H H C C C C C C C C C C C C C C C C C C C H H H H H H C S S C C C C C C C H H S S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C S S S S S S S S S H H C C C

 Solvent Accessibility
6 3 2 0 0 0 0 0 0 0 0 0 1 3 3 2 4 4 3 4 4 4 4 3 3 4 4 4 3 3 4 4 3 4 4 4 3 4 3 2 3 2 3 3 5 4 3 4 2 3 3 4 5 4 4 2 4 3 4 4 3 3 2 3 3 4 4 4 4 2 3 4 4 3 1 1 3 0 4 4 4 3 3 3 3 3 3 3 2 2 2 3 4 4 4 4 4 4 2 3 4 3 3 3 2 3 2 3 4 4 3 3 3 3 4 3 3 2 3 4 4 3 3 3 3 4 3 3 4 4 1 2 2 2 3 3 7 3 3 4 4 4 3 2 4 4 3 3 3 3 4 4 2 4 4 3 4 4 4 4 3 3 4 3 3 4 3 3 3 4 3 2 4 1 4 4 4 4 4 2 3 3 3 6 4 4 3 3 3 4 3 0 2 3 0 0 3 1 2 0 4 4 3 3 5 3 3 6 4 3 4 4 4 4 4 4 3 4 3 3 3 4 4 4 4 3 4 2 4 4 1 0 4 3 0 3 0 6 3 3 4 3 0 3 3 0 0 0 2 0 5 3 4 3 4 1 0 0 0 2 2 0 0 3 4 5 3 5 5 5 5 4 3 3 3 3 4 3 0 1 0 0 0 0 0 1 0 0 3 1 1 4 7 8
Values range from 0 (buried residue) to 9 (highly exposed residue)

 Download the alignment file (Protein and Template )
 
 Download Models

Model 1 Model 2 Model 3 Model 4 Model 5


Ramachandran Plot

Checks the stereochemical quality of a protein structure by analyzing residue-by-residue geometry and overall structure geometry.   Click here for Ramachandran plot of FDT014
ERRAT

Analyzes the statistics of non-bonded interactions between different atom types and plots the value of the error function versus position of a 9-residue sliding window, calculated by a comparison with statistics from highly refined structures.  Click here for ERRAT plot ofFDT014
PROVE

Calculates the volumes of atoms in macromolecules using an algorithm which treats the atoms like hard spheres and calculates a statistical Z-score deviation for the model from highly resolved (2.0 or better) and refined (R-factor of 0.2 or better) PDB-deposited structures.    Click here for PROVE plot of FDT014

  
                                   Active site residues                                      
Pockets   On  Off Residues
Site 1      89,90,97,148;
Site 2      72,74,75,89;
Site 3      120,128,129;
Site 4     87,89,98;
Site 5     138,139,145,177,178;
Site 6     88,90,91,98;
                                   Representation                                            
 
 



KEGG Pathway Not found for this protein
Drug target from Brugia malayi (Filarial nematode worm)



General Information  
   
FiloBase ID FDT014
Protein Name Putative uncharacterized protein
EMBL ID A8Q7A6
UniProtKB/TrEMBL ID A8Q7A6
GenBank ID 158591941
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_45135 
Taxonomic Identifier 6279
Source Brugia malayi (Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_45135 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software I-TASSER (Iterative Threading ASSEmbly Refinement)
Method Threading
   
Templates 1tic 
1tgl 
3ngm 
1tia 
1dt5 
3o0d 
2yij 
3uuf 
3g7n 
1usw 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL. ;Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea
PubMed ID 17885136
Full text link Full text   


General Information  
   
FiloBase ID FDT014
Protein Name Putative uncharacterized protein
EMBL ID A8Q7A6
UniProtKB/TrEMBL ID A8Q7A6
GenBank ID 158591941
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_45135 
Taxonomic Identifier 6279
Source Brugia malayi (Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_45135 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software I-TASSER (Iterative Threading ASSEmbly Refinement)
Method Threading
   
Templates 1tic 
1tgl 
3ngm 
1tia 
1dt5 
3o0d 
2yij 
3uuf 
3g7n 
1usw 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL. ;Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea
PubMed ID 17885136
Full text link Full text   


 Sequene
FASTA format   Full sequence
M Y K V I I C L L L L T P R I A N A F K I G I G G K N R G S S A A R L N P S R P N T H S S A G G Y H Q P Q G A Y H P Q Q S G Y Y P Q Q G G Y P Q Q G G Y R P Q Q N G Y H Q T A P G G Y H P S Q I G G Y H Q Q S G F A P N Q M K P S G K G T F G K A V L G G A L G A A A G L A T F E L G K A T V L I T A I Y L D C W H I L Q L N V L H A I L R S G S E P L R A S N G Q N Y Y F D E R N H Q Y K N G Y F M C S V P I D D V L K T L Q G S S T V V A A A D E S T N S T A I S P E Q F F K T V H F K D G S R P K S L T W N C K S D A E I C C D T D C C P V Q Q L S G G N F S D H K R P S W V F F I R F V D I L K S E

The amino acid color is based upon Bob Fletterick's 'Shapely Models'.(Ref. & Table)
 Sequene Length

294  amino acid

 Secondary Structure
Graphical View

Notice: Undefined variable: result in /opt/lampp/htdocs/filobase/drugt.php on line 193
C C S S S S S S S S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C H H H H C C C C C C C C C C C C C C C C C C C H H H H H H C S S C C C C C C C H H S S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C S S S S S S S S S H H C C C

 Solvent Accessibility
6 3 2 0 0 0 0 0 0 0 0 0 1 3 3 2 4 4 3 4 4 4 4 3 3 4 4 4 3 3 4 4 3 4 4 4 3 4 3 2 3 2 3 3 5 4 3 4 2 3 3 4 5 4 4 2 4 3 4 4 3 3 2 3 3 4 4 4 4 2 3 4 4 3 1 1 3 0 4 4 4 3 3 3 3 3 3 3 2 2 2 3 4 4 4 4 4 4 2 3 4 3 3 3 2 3 2 3 4 4 3 3 3 3 4 3 3 2 3 4 4 3 3 3 3 4 3 3 4 4 1 2 2 2 3 3 7 3 3 4 4 4 3 2 4 4 3 3 3 3 4 4 2 4 4 3 4 4 4 4 3 3 4 3 3 4 3 3 3 4 3 2 4 1 4 4 4 4 4 2 3 3 3 6 4 4 3 3 3 4 3 0 2 3 0 0 3 1 2 0 4 4 3 3 5 3 3 6 4 3 4 4 4 4 4 4 3 4 3 3 3 4 4 4 4 3 4 2 4 4 1 0 4 3 0 3 0 6 3 3 4 3 0 3 3 0 0 0 2 0 5 3 4 3 4 1 0 0 0 2 2 0 0 3 4 5 3 5 5 5 5 4 3 3 3 3 4 3 0 1 0 0 0 0 0 1 0 0 3 1 1 4 7 8
Values range from 0 (buried residue) to 9 (highly exposed residue)

 Download the alignment file (Protein and Template )
 
 Download Models

Model 1 Model 2 Model 3 Model 4 Model 5


Ramachandran Plot

Checks the stereochemical quality of a protein structure by analyzing residue-by-residue geometry and overall structure geometry.   Click here for Ramachandran plot of FDT014
ERRAT

Analyzes the statistics of non-bonded interactions between different atom types and plots the value of the error function versus position of a 9-residue sliding window, calculated by a comparison with statistics from highly refined structures.  Click here for ERRAT plot ofFDT014
PROVE

Calculates the volumes of atoms in macromolecules using an algorithm which treats the atoms like hard spheres and calculates a statistical Z-score deviation for the model from highly resolved (2.0 or better) and refined (R-factor of 0.2 or better) PDB-deposited structures.    Click here for PROVE plot of FDT014

  
                                   Active site residues                                      
Pockets   On  Off Residues
Site 1      89,90,97,148;
Site 2      72,74,75,89;
Site 3      120,128,129;
Site 4     87,89,98;
Site 5     138,139,145,177,178;
Site 6     88,90,91,98;
                                   Representation                                            
 
 



KEGG Pathway Not found for this protein