Drug target from Brugia malayi (Filarial nematode worm)



General Information  
   
FiloBase ID FDT030
Protein Name LBP / BPI / CETP family;C-terminal domain containing protein
EMBL ID A8PRQ0
UniProtKB/TrEMBL ID A8PRQ0
GenBank ID 158594244
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_32730 
Taxonomic Identifier 6279
Source Brugia malayi (Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_32730 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software Model method not found
Method Method not found
   
Templates 1bp1 
1ewf 
1ewf 
1ewf 
1bp1 
1ewf 
1bp1 
2obd 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL
PubMed ID 17885136
Full text link Full text   


General Information  
   
FiloBase ID FDT030
Protein Name LBP / BPI / CETP family;C-terminal domain containing protein
EMBL ID A8PRQ0
UniProtKB/TrEMBL ID A8PRQ0
GenBank ID 158594244
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_32730 
Taxonomic Identifier 6279
Source Brugia malayi (Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_32730 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software Model method not found
Method Method not found
   
Templates 1bp1 
1ewf 
1ewf 
1ewf 
1bp1 
1ewf 
1bp1 
2obd 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL
PubMed ID 17885136
Full text link Full text   


 Sequene
FASTA format   Full sequence
M I L Q L I F V T L Q L Y G L T N S H S L A S E T F F S F P F D N S Y G T D Q K H L T L L S R A V K N S F F T N P N T H A G F V T R I N Q K A L D L L A D Y L K E R V N R F M Y H G E I I F N F S A P L T N E V T F G L I S T K A I G Y D S K I F K S R L F I V P G Q G I I W M G S H L N L S I G T F F K I S S P A G D F Y G S A V L Q I N S A K V K S F F V A A V N V D G H L R T D L Q K C T L S P G N V V M N F S E T D P S L L V N Y Y P Q I N R F I S E R I E L I I C S S F N A E L V P V I S N R L M N T P M S A A L F D Q Y F V N Y G F I E Q I Q Y L P N A I E L K H R G N T F S I V K Q G L N R L N D F R L P F P S T P I T L D S P E N Q A M V E F T M S N Y T L A S L L Y W M D Q Y R N F D Y E I S K E S I N N T L M V G Y L R S E C S S N D I C A G T L F P A L S V Q Y P N G M V Q I K S H T T T P P T V R F E Q D K G I I V I W S Q V D A F V Q Q G E H T S P F L T S N M M A E L K L E K S I F Q N Y S F T S Q M R I D K F K I S D V T S L I D G I D K T S L E F L V S A L N E L L I G D D V A K K L S D G I K L P I L F D F V Q K S A N V I F E K D R M R I A V D F C F D Q N C S K N S I A E S N D F D Y Y D N V N S T S T L S

The amino acid color is based upon Bob Fletterick's 'Shapely Models'.(Ref. & Table)
 Sequene Length

553  amino acid

 Secondary Structure
Graphical View

Notice: Undefined variable: result in /opt/lampp/htdocs/filobase/drugt.php on line 193
C C H H H H H H H H H H H H H H C C C C C C C C S S S S C C C C C C C C C C C H H H H H H H H H H H H H H C C C C C C C C C S S S S S C H H H H H H H H H H H H H H H H H H H H H C C C C C C C C C C C C C S S S S S S S S S S S S S S C C C C C C C S S S S C C C C S S S S S S C C C S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S C C C C C S S S S S C C C C S S S S S S S S S S C C C C H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H C C C C C C C C C C S S S S S S S C C C C C S C C C S S S S S C C S S S S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C S S S S S S C H H H H H H H H H H H H H C C C S S S S S C C C C C C C C C C C C C S C C C C C C C H H H H H H H H H H H H H H C C C C C S S S S S S S C C C C S S S S S C C C S S S S S S S S S S S S S S C C C C C C S S S S S S S S S S S S S S S S S S C C C S S S S S S S S C C S S S S S S C C C C C C C C H H H H H H H H H H H H H H H H H H H H H H H H H C C C C C C C C C C C S S S C C S S S S S C C S S S S S S C C C C C H H H H H H H H C C C C C C C C C C C C C C C C C C C

 Solvent Accessibility
4 0 0 2 0 0 0 0 0 0 1 0 1 0 0 0 3 3 2 3 0 2 3 3 0 0 1 1 1 2 1 5 3 2 3 1 1 3 1 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 3 3 3 2 3 1 0 0 0 0 0 0 0 0 3 3 0 0 4 1 0 1 5 2 0 1 4 2 0 3 5 2 0 4 6 3 4 1 3 3 4 3 4 3 4 3 1 1 4 0 3 0 2 0 1 3 0 3 0 3 3 0 4 1 4 2 2 3 0 3 0 3 0 1 2 4 3 1 0 2 0 0 0 2 2 0 2 0 2 0 2 0 2 0 3 0 2 2 1 1 0 3 1 3 0 2 0 2 0 3 0 3 3 1 3 0 2 0 2 0 3 0 3 3 2 4 4 0 3 0 3 0 2 0 3 3 0 3 0 2 0 3 3 0 2 0 3 0 3 2 3 1 0 0 0 0 2 0 0 2 4 2 0 3 5 2 0 3 5 2 0 4 6 3 1 1 5 3 0 3 4 2 0 2 4 2 0 3 4 2 0 3 3 1 2 2 3 1 3 1 2 3 2 0 1 0 1 0 1 0 1 3 3 0 3 1 2 3 4 2 0 2 1 2 0 3 0 1 0 0 1 3 3 4 4 3 3 3 3 3 3 3 3 3 1 2 1 3 1 2 3 0 4 1 3 4 4 5 3 3 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 3 2 3 2 0 3 0 3 0 3 4 6 3 0 3 5 4 3 3 3 3 2 0 3 1 3 1 3 3 3 1 2 0 0 1 2 0 0 1 2 0 0 4 3 0 2 6 2 3 0 2 0 1 0 2 0 3 3 1 0 2 0 1 0 3 3 6 3 0 2 0 2 0 3 0 2 0 0 0 0 0 2 3 6 7 4 4 2 1 0 0 1 0 2 1 2 1 3 2 3 0 3 2 2 2 2 3 4 2 2 0 1 0 2 0 3 0 4 3 0 3 0 3 0 3 3 0 4 1 3 5 0 3 3 4 2 0 3 3 0 0 3 1 0 0 3 1 0 0 1 1 1 0 1 4 2 0 3 3 1 0 1 0 0 2 0 4 6 0 4 0 3 2 0 3 0 3 2 2 4 1 0 0 0 0 0 0 1 0 3 0 3 4 5 2 1 3 5 1 1 5 5 2 4 4 0 3 2 3 2 3 3 4 4 4 4 4 2 8
Values range from 0 (buried residue) to 9 (highly exposed residue)

 Download the alignment file (Protein and Template )
 
 Download Models

Model 1 Model 2 Model 3 Model 4 Model 5


Ramachandran Plot

Checks the stereochemical quality of a protein structure by analyzing residue-by-residue geometry and overall structure geometry.   Click here for Ramachandran plot of FDT030
ERRAT

Analyzes the statistics of non-bonded interactions between different atom types and plots the value of the error function versus position of a 9-residue sliding window, calculated by a comparison with statistics from highly refined structures.  Click here for ERRAT plot ofFDT030
PROVE

Calculates the volumes of atoms in macromolecules using an algorithm which treats the atoms like hard spheres and calculates a statistical Z-score deviation for the model from highly resolved (2.0 or better) and refined (R-factor of 0.2 or better) PDB-deposited structures.    Click here for PROVE plot of FDT030

  
                                   Active site residues                                      
Pockets   On  Off Residues
Site 1      63,67,79,133,135,172,174,184,186;
Site 2      75,80,83,125,244,247,317,319,523,529,530,533;
Site 3      142,195,225,226,229;
Site 4     457,472,475;
Site 5     139,168,169,197;
Site 6     275,279,317,319,523;
                                   Representation                                            
 
 



KEGG Pathway Not found for this protein
Drug target from Brugia malayi (Filarial nematode worm)



General Information  
   
FiloBase ID FDT030
Protein Name LBP / BPI / CETP family;C-terminal domain containing protein
EMBL ID A8PRQ0
UniProtKB/TrEMBL ID A8PRQ0
GenBank ID 158594244
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_32730 
Taxonomic Identifier 6279
Source Brugia malayi (Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_32730 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software Model method not found
Method Method not found
   
Templates 1bp1 
1ewf 
1ewf 
1ewf 
1bp1 
1ewf 
1bp1 
2obd 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL
PubMed ID 17885136
Full text link Full text   


General Information  
   
FiloBase ID FDT030
Protein Name LBP / BPI / CETP family;C-terminal domain containing protein
EMBL ID A8PRQ0
UniProtKB/TrEMBL ID A8PRQ0
GenBank ID 158594244
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_32730 
Taxonomic Identifier 6279
Source Brugia malayi (Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_32730 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software Model method not found
Method Method not found
   
Templates 1bp1 
1ewf 
1ewf 
1ewf 
1bp1 
1ewf 
1bp1 
2obd 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL
PubMed ID 17885136
Full text link Full text   


 Sequene
FASTA format   Full sequence
M I L Q L I F V T L Q L Y G L T N S H S L A S E T F F S F P F D N S Y G T D Q K H L T L L S R A V K N S F F T N P N T H A G F V T R I N Q K A L D L L A D Y L K E R V N R F M Y H G E I I F N F S A P L T N E V T F G L I S T K A I G Y D S K I F K S R L F I V P G Q G I I W M G S H L N L S I G T F F K I S S P A G D F Y G S A V L Q I N S A K V K S F F V A A V N V D G H L R T D L Q K C T L S P G N V V M N F S E T D P S L L V N Y Y P Q I N R F I S E R I E L I I C S S F N A E L V P V I S N R L M N T P M S A A L F D Q Y F V N Y G F I E Q I Q Y L P N A I E L K H R G N T F S I V K Q G L N R L N D F R L P F P S T P I T L D S P E N Q A M V E F T M S N Y T L A S L L Y W M D Q Y R N F D Y E I S K E S I N N T L M V G Y L R S E C S S N D I C A G T L F P A L S V Q Y P N G M V Q I K S H T T T P P T V R F E Q D K G I I V I W S Q V D A F V Q Q G E H T S P F L T S N M M A E L K L E K S I F Q N Y S F T S Q M R I D K F K I S D V T S L I D G I D K T S L E F L V S A L N E L L I G D D V A K K L S D G I K L P I L F D F V Q K S A N V I F E K D R M R I A V D F C F D Q N C S K N S I A E S N D F D Y Y D N V N S T S T L S

The amino acid color is based upon Bob Fletterick's 'Shapely Models'.(Ref. & Table)
 Sequene Length

553  amino acid

 Secondary Structure
Graphical View

Notice: Undefined variable: result in /opt/lampp/htdocs/filobase/drugt.php on line 193
C C H H H H H H H H H H H H H H C C C C C C C C S S S S C C C C C C C C C C C H H H H H H H H H H H H H H C C C C C C C C C S S S S S C H H H H H H H H H H H H H H H H H H H H H C C C C C C C C C C C C C S S S S S S S S S S S S S S C C C C C C C S S S S C C C C S S S S S S C C C S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S C C C C C S S S S S C C C C S S S S S S S S S S C C C C H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H C C C C C C C C C C S S S S S S S C C C C C S C C C S S S S S C C S S S S S C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C S S S S S S C H H H H H H H H H H H H H C C C S S S S S C C C C C C C C C C C C C S C C C C C C C H H H H H H H H H H H H H H C C C C C S S S S S S S C C C C S S S S S C C C S S S S S S S S S S S S S S C C C C C C S S S S S S S S S S S S S S S S S S C C C S S S S S S S S C C S S S S S S C C C C C C C C H H H H H H H H H H H H H H H H H H H H H H H H H C C C C C C C C C C C S S S C C S S S S S C C S S S S S S C C C C C H H H H H H H H C C C C C C C C C C C C C C C C C C C

 Solvent Accessibility
4 0 0 2 0 0 0 0 0 0 1 0 1 0 0 0 3 3 2 3 0 2 3 3 0 0 1 1 1 2 1 5 3 2 3 1 1 3 1 1 0 0 0 0 0 0 0 0 0 0 0 0 1 1 3 3 3 2 3 1 0 0 0 0 0 0 0 0 3 3 0 0 4 1 0 1 5 2 0 1 4 2 0 3 5 2 0 4 6 3 4 1 3 3 4 3 4 3 4 3 1 1 4 0 3 0 2 0 1 3 0 3 0 3 3 0 4 1 4 2 2 3 0 3 0 3 0 1 2 4 3 1 0 2 0 0 0 2 2 0 2 0 2 0 2 0 2 0 3 0 2 2 1 1 0 3 1 3 0 2 0 2 0 3 0 3 3 1 3 0 2 0 2 0 3 0 3 3 2 4 4 0 3 0 3 0 2 0 3 3 0 3 0 2 0 3 3 0 2 0 3 0 3 2 3 1 0 0 0 0 2 0 0 2 4 2 0 3 5 2 0 3 5 2 0 4 6 3 1 1 5 3 0 3 4 2 0 2 4 2 0 3 4 2 0 3 3 1 2 2 3 1 3 1 2 3 2 0 1 0 1 0 1 0 1 3 3 0 3 1 2 3 4 2 0 2 1 2 0 3 0 1 0 0 1 3 3 4 4 3 3 3 3 3 3 3 3 3 1 2 1 3 1 2 3 0 4 1 3 4 4 5 3 3 1 0 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 1 3 2 3 2 0 3 0 3 0 3 4 6 3 0 3 5 4 3 3 3 3 2 0 3 1 3 1 3 3 3 1 2 0 0 1 2 0 0 1 2 0 0 4 3 0 2 6 2 3 0 2 0 1 0 2 0 3 3 1 0 2 0 1 0 3 3 6 3 0 2 0 2 0 3 0 2 0 0 0 0 0 2 3 6 7 4 4 2 1 0 0 1 0 2 1 2 1 3 2 3 0 3 2 2 2 2 3 4 2 2 0 1 0 2 0 3 0 4 3 0 3 0 3 0 3 3 0 4 1 3 5 0 3 3 4 2 0 3 3 0 0 3 1 0 0 3 1 0 0 1 1 1 0 1 4 2 0 3 3 1 0 1 0 0 2 0 4 6 0 4 0 3 2 0 3 0 3 2 2 4 1 0 0 0 0 0 0 1 0 3 0 3 4 5 2 1 3 5 1 1 5 5 2 4 4 0 3 2 3 2 3 3 4 4 4 4 4 2 8
Values range from 0 (buried residue) to 9 (highly exposed residue)

 Download the alignment file (Protein and Template )
 
 Download Models

Model 1 Model 2 Model 3 Model 4 Model 5


Ramachandran Plot

Checks the stereochemical quality of a protein structure by analyzing residue-by-residue geometry and overall structure geometry.   Click here for Ramachandran plot of FDT030
ERRAT

Analyzes the statistics of non-bonded interactions between different atom types and plots the value of the error function versus position of a 9-residue sliding window, calculated by a comparison with statistics from highly refined structures.  Click here for ERRAT plot ofFDT030
PROVE

Calculates the volumes of atoms in macromolecules using an algorithm which treats the atoms like hard spheres and calculates a statistical Z-score deviation for the model from highly resolved (2.0 or better) and refined (R-factor of 0.2 or better) PDB-deposited structures.    Click here for PROVE plot of FDT030

  
                                   Active site residues                                      
Pockets   On  Off Residues
Site 1      63,67,79,133,135,172,174,184,186;
Site 2      75,80,83,125,244,247,317,319,523,529,530,533;
Site 3      142,195,225,226,229;
Site 4     457,472,475;
Site 5     139,168,169,197;
Site 6     275,279,317,319,523;
                                   Representation                                            
 
 



KEGG Pathway Not found for this protein