Drug target from Brugia malayi (Filarial nematode worm)



General Information  
   
FiloBase ID FDT031
Protein Name hypothetical protein
EMBL ID A8Q420
UniProtKB/TrEMBL ID A8Q420
GenBank ID 158592480
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_42470 
Taxonomic Identifier 6279
Source Brugia malayi (Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_42470 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software Model method not found
Method Method not found
   
Templates 3tvs 
3vvv 
1gca 
3ejn 
4job 
1xx0 
3vr8 
2uvg 
2sas 
3ck9B 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL
PubMed ID 17885136
Full text link Full text   


General Information  
   
FiloBase ID FDT031
Protein Name hypothetical protein
EMBL ID A8Q420
UniProtKB/TrEMBL ID A8Q420
GenBank ID 158592480
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_42470 
Taxonomic Identifier 6279
Source Brugia malayi (Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_42470 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software Model method not found
Method Method not found
   
Templates 3tvs 
3vvv 
1gca 
3ejn 
4job 
1xx0 
3vr8 
2uvg 
2sas 
3ck9B 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL
PubMed ID 17885136
Full text link Full text   


 Sequene
FASTA format   Full sequence
M A E T C D E P L R A T Y T P A R P P W I G Y W N K R W N Q R D Q S K S R K V W W T E L G W T D S A T E S G K M C F A G P Q L R E H D P E Y Y D P K V P D G T S L A G P M G L D S T R Y P N L T R K G D Q P G N Y E E F M N K L Y K S S T Q Y K D I A A K Y E L T E G P W P H H K G L K V M R A N N N Y H E F L A R Y K T S W W M P K L F R F F N S P L N E D P I I K G L A C A Q Y T A F L L I P Y T G L H I R G H N I L P V P V T P L S I L K T Y F K L L P T P A T L A F T W G I T L S G A A M I R H K D D F M N H L Y A S T A S G I V F A T M R D N F L A G F S L G F I V Y I T G L C W Q Y M R V S E W S L Q N K V I H R K S G S F Y G G P L V W K L K W K G G E E E I P T K K W

The amino acid color is based upon Bob Fletterick's 'Shapely Models'.(Ref. & Table)
 Sequene Length

331  amino acid

 Secondary Structure
Graphical View

Notice: Undefined variable: result in /opt/lampp/htdocs/filobase/drugt.php on line 193
C C C C C C C C C H C C C C C C C C C S S S S C C C C C C C C C C C C C C C H H H H C C C C C C C C C C C C C S S S C C C H C C C C C C H C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C H H H H H H H H H C C C C H H H H H H H H C C C C C C C C C C C C C C C C C C C C C H H H H H H H H C C C C C C C C C C C C C C C C C C C C C H H H H H H H H H H H H H H H C C C C C S S S S S S C S S S C C C C C C H H H H H H H H H H C C C C H H H H H H H H H H H H H H H H H C C C H H H H H H H H H H H C C C C S S C H H H H H H H H H H H H H H H H H H H H H H H H H H H H C C C C C C C C C C C C C C C C C C C C C H H H H H H H H C C C C C C C C C C C

 Solvent Accessibility
7 4 5 3 1 5 4 3 0 4 2 4 1 4 3 6 3 1 1 0 0 0 1 0 2 5 3 1 4 4 4 4 5 4 5 2 2 3 3 0 0 4 4 2 3 2 5 4 3 1 4 5 4 2 3 1 2 0 2 3 3 4 1 4 6 4 4 2 6 3 1 4 1 6 0 5 5 3 5 4 2 1 1 2 2 2 3 3 3 5 5 3 4 5 0 3 4 4 2 7 4 3 2 4 2 6 5 0 1 4 3 0 2 5 4 3 4 3 0 3 4 0 1 6 4 1 4 0 4 5 4 4 3 4 5 2 3 2 1 3 0 2 3 2 1 4 4 2 3 4 3 1 3 4 3 3 2 3 2 1 1 2 3 0 0 4 2 1 3 2 3 3 3 6 4 2 1 2 3 1 1 2 0 3 3 0 0 0 0 0 2 0 1 2 0 0 0 2 0 1 0 1 2 1 0 3 1 2 1 3 3 3 4 1 0 3 3 0 2 4 2 0 3 2 2 1 1 2 0 2 0 1 1 1 2 1 2 1 0 1 3 1 3 4 4 5 3 1 2 2 1 0 1 0 0 1 0 0 1 0 0 1 0 1 2 3 3 3 2 0 1 0 1 0 0 0 0 0 0 0 0 0 1 1 0 1 3 0 2 3 3 3 5 2 4 0 3 4 4 3 3 3 4 4 3 1 1 0 1 0 1 1 0 1 1 3 1 3 1 4 2 3 4 5 7 1 3 5 6 6 7
Values range from 0 (buried residue) to 9 (highly exposed residue)

 Download the alignment file (Protein and Template )
 
 Download Models

Model 1 Model 2 Model 3 Model 4 Model 5


Ramachandran Plot

Checks the stereochemical quality of a protein structure by analyzing residue-by-residue geometry and overall structure geometry.   Click here for Ramachandran plot of FDT031
ERRAT

Analyzes the statistics of non-bonded interactions between different atom types and plots the value of the error function versus position of a 9-residue sliding window, calculated by a comparison with statistics from highly refined structures.  Click here for ERRAT plot ofFDT031
PROVE

Calculates the volumes of atoms in macromolecules using an algorithm which treats the atoms like hard spheres and calculates a statistical Z-score deviation for the model from highly resolved (2.0 or better) and refined (R-factor of 0.2 or better) PDB-deposited structures.    Click here for PROVE plot of FDT031

  
                                   Active site residues                                      
Pockets   On  Off Residues
Site 1      134,200,202,294;
Site 2      23,134,136,198,200,200;
Site 3      89,90,157,164,166,191,192,194;
Site 4     Not available.;
Site 5     Not available.;
Site 6     Not available.;
                                   Representation                                            
 
 



KEGG Pathway Not found for this protein
Drug target from Brugia malayi (Filarial nematode worm)



General Information  
   
FiloBase ID FDT031
Protein Name hypothetical protein
EMBL ID A8Q420
UniProtKB/TrEMBL ID A8Q420
GenBank ID 158592480
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_42470 
Taxonomic Identifier 6279
Source Brugia malayi (Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_42470 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software Model method not found
Method Method not found
   
Templates 3tvs 
3vvv 
1gca 
3ejn 
4job 
1xx0 
3vr8 
2uvg 
2sas 
3ck9B 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL
PubMed ID 17885136
Full text link Full text   


General Information  
   
FiloBase ID FDT031
Protein Name hypothetical protein
EMBL ID A8Q420
UniProtKB/TrEMBL ID A8Q420
GenBank ID 158592480
Subcellular Localization Cytoplasmic/Inner Membrane
Locus Tag Bm1_42470 
Taxonomic Identifier 6279
Source Brugia malayi (Filarial nematode worm)
Lineage Eukaryota->Metazoa->Nematoda->Chromadorea->Spirurida->Filarioidea->Onchocercidae->Brugia
KEGG IDBm1_42470 
KEGG Database

SSDB Motif Search SSDB
   
Model Information  
   
Software Model method not found
Method Method not found
   
Templates 3tvs 
3vvv 
1gca 
3ejn 
4job 
1xx0 
3vr8 
2uvg 
2sas 
3ck9B 
   
Literature Information  
   
   
Reference Ghedin E;Wang S;Spiro D;Caler E;Zhao Q;Crabtree J;Allen JE;Delcher AL;Guiliano DB;Miranda-Saavedra D;Angiuoli SV;Creasy T;Amedeo P;Haas B;El-Sayed NM;Wortman JR;Feldblyum T;Tallon L;Schatz M;Shumway M;Koo H;Salzberg SL;Schobel S;Pertea M;Pop M;White O;Barton GJ;Carlow CK;Crawford MJ;Daub J;Dimmic MW;Estes CF;Foster JM;Ganatra M;Gregory WF;Johnson NM;Jin J;Komuniecki R;Korf I;Kumar S;Laney S;Li BW;Li W;Lindblom TH;Lustigman S;Ma D;Maina CV;Martin DM;McCarter JP;McReynolds L;Mitreva M;Nutman TB;Parkinson J;Peregr?n-Alvarez JM;Poole C;Ren Q;Saunders L;Sluder AE;Smith K;Stanke M;Unnasch TR;Ware J;Wei AD;Weil G;Williams DJ;Zhang Y;Williams SA;Fraser-Liggett C;Slatko B;Blaxter ML;Scott AL
PubMed ID 17885136
Full text link Full text   


 Sequene
FASTA format   Full sequence
M A E T C D E P L R A T Y T P A R P P W I G Y W N K R W N Q R D Q S K S R K V W W T E L G W T D S A T E S G K M C F A G P Q L R E H D P E Y Y D P K V P D G T S L A G P M G L D S T R Y P N L T R K G D Q P G N Y E E F M N K L Y K S S T Q Y K D I A A K Y E L T E G P W P H H K G L K V M R A N N N Y H E F L A R Y K T S W W M P K L F R F F N S P L N E D P I I K G L A C A Q Y T A F L L I P Y T G L H I R G H N I L P V P V T P L S I L K T Y F K L L P T P A T L A F T W G I T L S G A A M I R H K D D F M N H L Y A S T A S G I V F A T M R D N F L A G F S L G F I V Y I T G L C W Q Y M R V S E W S L Q N K V I H R K S G S F Y G G P L V W K L K W K G G E E E I P T K K W

The amino acid color is based upon Bob Fletterick's 'Shapely Models'.(Ref. & Table)
 Sequene Length

331  amino acid

 Secondary Structure
Graphical View

Notice: Undefined variable: result in /opt/lampp/htdocs/filobase/drugt.php on line 193
C C C C C C C C C H C C C C C C C C C S S S S C C C C C C C C C C C C C C C H H H H C C C C C C C C C C C C C S S S C C C H C C C C C C H C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C C H H H H H H H H H C C C C H H H H H H H H C C C C C C C C C C C C C C C C C C C C C H H H H H H H H C C C C C C C C C C C C C C C C C C C C C H H H H H H H H H H H H H H H C C C C C S S S S S S C S S S C C C C C C H H H H H H H H H H C C C C H H H H H H H H H H H H H H H H H C C C H H H H H H H H H H H C C C C S S C H H H H H H H H H H H H H H H H H H H H H H H H H H H H C C C C C C C C C C C C C C C C C C C C C H H H H H H H H C C C C C C C C C C C

 Solvent Accessibility
7 4 5 3 1 5 4 3 0 4 2 4 1 4 3 6 3 1 1 0 0 0 1 0 2 5 3 1 4 4 4 4 5 4 5 2 2 3 3 0 0 4 4 2 3 2 5 4 3 1 4 5 4 2 3 1 2 0 2 3 3 4 1 4 6 4 4 2 6 3 1 4 1 6 0 5 5 3 5 4 2 1 1 2 2 2 3 3 3 5 5 3 4 5 0 3 4 4 2 7 4 3 2 4 2 6 5 0 1 4 3 0 2 5 4 3 4 3 0 3 4 0 1 6 4 1 4 0 4 5 4 4 3 4 5 2 3 2 1 3 0 2 3 2 1 4 4 2 3 4 3 1 3 4 3 3 2 3 2 1 1 2 3 0 0 4 2 1 3 2 3 3 3 6 4 2 1 2 3 1 1 2 0 3 3 0 0 0 0 0 2 0 1 2 0 0 0 2 0 1 0 1 2 1 0 3 1 2 1 3 3 3 4 1 0 3 3 0 2 4 2 0 3 2 2 1 1 2 0 2 0 1 1 1 2 1 2 1 0 1 3 1 3 4 4 5 3 1 2 2 1 0 1 0 0 1 0 0 1 0 0 1 0 1 2 3 3 3 2 0 1 0 1 0 0 0 0 0 0 0 0 0 1 1 0 1 3 0 2 3 3 3 5 2 4 0 3 4 4 3 3 3 4 4 3 1 1 0 1 0 1 1 0 1 1 3 1 3 1 4 2 3 4 5 7 1 3 5 6 6 7
Values range from 0 (buried residue) to 9 (highly exposed residue)

 Download the alignment file (Protein and Template )
 
 Download Models

Model 1 Model 2 Model 3 Model 4 Model 5


Ramachandran Plot

Checks the stereochemical quality of a protein structure by analyzing residue-by-residue geometry and overall structure geometry.   Click here for Ramachandran plot of FDT031
ERRAT

Analyzes the statistics of non-bonded interactions between different atom types and plots the value of the error function versus position of a 9-residue sliding window, calculated by a comparison with statistics from highly refined structures.  Click here for ERRAT plot ofFDT031
PROVE

Calculates the volumes of atoms in macromolecules using an algorithm which treats the atoms like hard spheres and calculates a statistical Z-score deviation for the model from highly resolved (2.0 or better) and refined (R-factor of 0.2 or better) PDB-deposited structures.    Click here for PROVE plot of FDT031

  
                                   Active site residues                                      
Pockets   On  Off Residues
Site 1      134,200,202,294;
Site 2      23,134,136,198,200,200;
Site 3      89,90,157,164,166,191,192,194;
Site 4     Not available.;
Site 5     Not available.;
Site 6     Not available.;
                                   Representation                                            
 
 



KEGG Pathway Not found for this protein